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Short answer: not in any clinically meaningful way

Importantly, we were the first to underscore the significance of the precise omega-6/omega-3 fatty acid ratio and its correlation with the kynurenine pathway of TRP degradation (KYN/TRP ratio) in the pathophysiology of depressive disorders in children and adolescents

References 1 ReichDSLucchinettiCFCalabresiPA

Concurrent deficiencies in vitamin D, likely due to reduced sunlight exposure, and fluctuations in estradiol, progesterone, and DHEAS, especially among premenopausal women and extreme chronotypes, further exacerbate endocrine disruption 272

The substrates and products of the DHODH reaction have opposite effects on ferroptosis, suggesting that the potential role of DHODH in regulating ferroptosis sensitivity is independent of its function of producing pyrimidine nucleotides